For the most part, no. Once you make changes, LaunchPad does not go back and regrade the assignment. Thus, there will be inconsistent grading if changes are made to any of the below settings.
The only setting that can be changed without impacting grading is the due date. Changing anything else will cause inconsistent grading.
Inconsistent grading will occur if changes are made to Number of Attempts or Scored Attempts. You can make changes to any other settings without impacting grading.
Any change here will impact grading. Do not make changes to questions once students have begun the assignment.